Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

Nat Genet. 2009 Jun;41(6):648-50. doi: 10.1038/ng.386. Epub 2009 May 17.

Abstract

We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Age Factors
  • Body Mass Index
  • Child
  • Chromosome Mapping
  • Chromosomes, Human, Pair 6 / genetics
  • Chromosomes, Human, Pair 8 / genetics
  • Chromosomes, Human, Pair 9 / genetics*
  • DNA-Binding Proteins / genetics
  • Female
  • Genetic Variation
  • Genome-Wide Association Study*
  • Humans
  • Menarche / genetics*
  • Meta-Analysis as Topic
  • Polymorphism, Single Nucleotide
  • RNA-Binding Proteins
  • Sexual Maturation / genetics

Substances

  • DNA-Binding Proteins
  • LIN28B protein, human
  • RNA-Binding Proteins

Grant support