Netting neutrophils in autoimmune small-vessel vasculitis

Nat Med. 2009 Jun;15(6):623-5. doi: 10.1038/nm.1959.


Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 (PR3) and myeloperoxidase (MPO). Deposition of NETs in inflamed kidneys and circulating MPO-DNA complexes suggest that NET formation triggers vasculitis and promotes the autoimmune response against neutrophil components in individuals with SVV.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoantigens / immunology
  • Autoimmune Diseases / immunology*
  • Microcirculation / immunology*
  • Myeloblastin / metabolism
  • Neutrophils / immunology*
  • Vasculitis / immunology*


  • Autoantigens
  • Myeloblastin