Additional genes which result in an elevation of acetylcholine levels by mutations in Caenorhabditis elegans

Neurosci Lett. 1991 Jul 22;128(2):243-4. doi: 10.1016/0304-3940(91)90270-4.


Four mutant genes (unc-17, unc-18, unc-41 and unc-13) have been identified that result in abnormal accumulation of acetylcholine (ACh). We have now identified 3 more such genes (unc-63, unc-11 and unc-64). In addition to the abnormal accumulation of ACh, mutants in these 7 genes possess common phenotypes in locomotion, resistance to inhibitors of acetylcholinesterase (AChE) and in post-embryonic development. These results suggest that the 7 genes are involved in some related functions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholine / metabolism*
  • Animals
  • Caenorhabditis / genetics*
  • Genotype
  • Mutation
  • Phenotype
  • Trichlorfon / pharmacology


  • Trichlorfon
  • Acetylcholine