The CULt of caspase-8 ubiquitination

Cell. 2009 May 15;137(4):604-6. doi: 10.1016/j.cell.2009.04.052.

Abstract

Caspase-8 is activated at the plasma membrane by the death-inducing signaling complex (DISC). Jin et al. (2009) show that polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC.

Publication types

  • Comment

MeSH terms

  • Apoptosis
  • Caspase 8 / metabolism*
  • Cullin Proteins / metabolism*
  • Death Domain Receptor Signaling Adaptor Proteins / metabolism
  • Humans
  • Ubiquitination

Substances

  • CUL3 protein, human
  • Cullin Proteins
  • Death Domain Receptor Signaling Adaptor Proteins
  • Caspase 8