The effects of carbon dioxide on measuring cerebral spinal fluid pressure

Childs Nerv Syst. 2009 Jul;25(7):783-4. doi: 10.1007/s00381-009-0902-y. Epub 2009 May 19.


Purpose: The effects of pCO2 on cerebral spinal fluid (CSF) pressure measurement were observed in four patients.

Methods: Children presenting with either a diagnosis or suspected diagnosis of IIH, who were undergoing lumbar puncture under a general anaesthetic for pressure measurement, were recruited to study the relationship between pCO2 and CSF pressure measurements.

Results: A rise of end-tidal pCO2 by 1 kPa causes a rise of CSF pressure by 3.5-12 cm H20.

Conclusion: Controlling of pCO2 is important when measuring CSF pressure to prevent misdiagnosis and over treatment of patients with idiopathic intracranial hypertension (IIH).

MeSH terms

  • Carbon Dioxide*
  • Cerebrospinal Fluid Pressure / physiology*
  • Child
  • Humans
  • Intracranial Hypertension / cerebrospinal fluid
  • Intracranial Hypertension / diagnosis
  • Intracranial Hypertension / metabolism
  • Spinal Puncture


  • Carbon Dioxide