Validation of the questionnaire for impulsive-compulsive disorders in Parkinson's disease

Mov Disord. 2009 Jul 30;24(10):1461-7. doi: 10.1002/mds.22571.

Abstract

As no comprehensive assessment instrument for impulse control disorders (ICDs) in Parkinson's disease (PD) exists, the aim of this study was to design and assess the psychometric properties of a self-administered screening questionnaire for ICDs and other compulsive behaviors in PD. The Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease (QUIP) has 3 sections: Section 1 assesses four ICDs (involving gambling, sexual, buying, and eating behaviors), Section 2 other compulsive behaviors (punding, hobbyism, and walkabout), and Section 3 compulsive medication use. For validation, a convenience sample of 157 PD patients at 4 movement disorders centers first completed the QUIP, and then was administered a diagnostic interview by a trained rater blinded to the QUIP results. A shortened instrument (QUIP-S) was then explored. The discriminant validity of the QUIP was high for each disorder or behavior (receiver operating characteristic area under the curve [ROC AUC]: gambling = 0.95, sexual behavior = 0.97, buying = 0.87, eating = 0.88, punding = 0.78, hobbyism = 0.93, walkabout = 0.79). On post hoc analysis, the QUIP-S ICD section had similar properties (ROC AUC: gambling = 0.95, sexual behavior = 0.96, buying = 0.87, eating = 0.88). When disorders/behaviors were combined, the sensitivity of the QUIP and QUIP-S to detect an individual with any disorder was 96 and 94%, respectively. Scores on the QUIP appear to be valid as a self-assessment screening instrument for a range of ICDs and other compulsive behaviors that occur in PD, and a shortened version may perform as well as the full version. A positive screen should be followed by a comprehensive, clinical interview to determine the range and severity of symptoms, as well as need for clinical management.

MeSH terms

  • Aged
  • Area Under Curve
  • Disruptive, Impulse Control, and Conduct Disorders / diagnosis*
  • Disruptive, Impulse Control, and Conduct Disorders / etiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / complications*
  • Predictive Value of Tests
  • Psychiatric Status Rating Scales
  • Psychometrics*
  • ROC Curve
  • Reproducibility of Results
  • Severity of Illness Index
  • Surveys and Questionnaires*