[The expression and relationship of cyclooxygenase-2 and latent membrane protein-1 in nasopharyngeal carcinoma]

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Feb;23(3):105-8.
[Article in Chinese]


Objective: To discuss the expression and correlation of COX2 and LMP1 in NPC.

Method: Fifty-three nasopharyngeal biopsy specimens of NPC patients who had been diagnosed definitely with pathology in our department from 2000 to 2005, and 8 nasopharyngeal biopsy specimens of chronic nasopharyngitis patients were collected. The expression of COX2, LMP1 were detected with streptavidin peroxidase immunohistochemistry staining. All the datas were analyzed with SPSS 12.0.

Result: The positive expression rate of COX2 was 71.70% (38/53), and that of LMP1 was 66.04% (35/53) of Nasopharyngeal carcinoma tissue. The higher expression rate was detected in neck lymph nodes metastasis group of nasopharyngeal carcinoma (P<0.05). While the expression rate of COX2, LMP1 was no significant relation with age, gender, clinical stage and pathological classification (P>0.05). The expression of COX2 and LMP1 showed positive correlation (gamma = 0.797, P<0.01).

Conclusion: COX2 and LMP1 were highly expressed in nasopharyngeal carcinoma cells. The expressions of COX2 and LMP1 was significantly associated with neck lymph nodes metastasis, and was none-significant relation with age, gender, clinical stage and pathological classification. The expression of LMP1 showed a significant positive correlation with that of COX2. LMP1 could enhance NPC neck lymph nodes metastasis by up-regulating the expression of COX2.

Publication types

  • English Abstract

MeSH terms

  • Carcinoma, Squamous Cell / metabolism
  • Carcinoma, Squamous Cell / pathology
  • Cyclooxygenase 2 / metabolism*
  • Female
  • Humans
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Nasal Mucosa / metabolism*
  • Nasal Mucosa / pathology
  • Nasopharyngeal Neoplasms / metabolism*
  • Nasopharyngeal Neoplasms / pathology
  • Neoplasm Staging
  • Viral Matrix Proteins / metabolism*


  • EBV-associated membrane antigen, Epstein-Barr virus
  • Viral Matrix Proteins
  • Cyclooxygenase 2
  • PTGS2 protein, human