Aspects of antioxidant foods and supplements in health and disease

Nutr Rev. 2009 May;67 Suppl 1:S140-4. doi: 10.1111/j.1753-4887.2009.00177.x.


Free radicals generated as byproducts of normal metabolism can damage biologically relevant molecules. When their generation is increased, damage can also be increased, resulting in the development of many pathological conditions. Antioxidant defenses protect the body from the detrimental effects of free radicals. Dietary fruits and vegetables provide a reasonable amount of compounds that act as physiological antioxidants. Although existing knowledge does not allow a final and conclusive assessment of the relevance of antioxidants for health, it does provide the basis for its rational consideration. This paper addresses the specific aspects of antioxidant supplementation in health and disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / drug effects
  • Aging / physiology*
  • Antioxidants / administration & dosage*
  • Antioxidants / pharmacology
  • Chronic Disease / prevention & control*
  • Dietary Supplements
  • Evidence-Based Medicine
  • Exercise / physiology
  • Food Analysis
  • Humans
  • Neoplasms / prevention & control*
  • Nutritive Value
  • Oxidative Stress / drug effects*
  • Oxidative Stress / physiology
  • Reactive Oxygen Species / adverse effects
  • Reactive Oxygen Species / metabolism


  • Antioxidants
  • Reactive Oxygen Species