Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect

G Yang; L Wu; S Chen; L Zhu; P Huang; L Tong; Y Zhao; G Zhao; J Wang; T Mei; A Xu; Y Wang

doi:10.1038/sj.bjc.6605087

Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect

Br J Cancer. 2009 Jun 16;100(12):1912-6. doi: 10.1038/sj.bjc.6605087. Epub 2009 May 19.

Authors

G Yang¹, L Wu, S Chen, L Zhu, P Huang, L Tong, Y Zhao, G Zhao, J Wang, T Mei, A Xu, Y Wang

Affiliation

¹ State Key Laboratory of Nuclear Physics and Technology, Peking University, Beijing 100871, People's Republic of China.

Abstract

Cytochrome c is a pivotal protein that resides in mitochondria as component of mitochondria respiration and apoptosis initiator. Using murine cells lacking cytochrome c, we showed here that cytochrome c-deficient cells had attenuated reactive oxygen species/nitric oxide and micronuclei induction to radiation-induced bystander signals, indicating cytochrome c is essential for the bystander effect.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apoptosis
Bystander Effect / radiation effects*
Cell Culture Techniques
Coculture Techniques
Cytochromes c / metabolism*
Gamma Rays
Membrane Potential, Mitochondrial
Mice
Mice, Knockout
Micronucleus Tests
Mitochondria / enzymology*
Mitochondria / pathology
Mitochondria / radiation effects*
Nitric Oxide / metabolism
Reactive Oxygen Species / metabolism

Substances

Reactive Oxygen Species
Nitric Oxide
Cytochromes c