Association study of the serotoninergic system in migraine in the Spanish population

Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):177-84. doi: 10.1002/ajmg.b.30972.


In order to evaluate the contribution of 19 serotonin-related genes to the susceptibility to migraine in a Spanish population we performed a case-control association study of 122 single nucleotide polymorphisms (SNPs), selected according to genetic coverage parameters, in 528 migraine patients -308 with migraine without aura (MO) and 220 with migraine with aura (MA)- and 528 sex-matched migraine-free controls. The single-marker analysis identified nominal associations with the migraine phenotype or with the MO or MA subtypes. The multiple-marker analysis revealed risk haplotypes in three genes that remained significantly associated with migraine after correction by permutations. Two-marker risk haplotypes were identified in the HTR2B (rs16827801T-rs10194776G) and MAOA (rs3027400G-rs2072743C) genes conferring susceptibility to MO, and a four-marker haplotype in DDC was specific of MA (rs2329340A-rs11974297C-rs2044859T-rs11761683G). The present study supports the involvement of HTR2B and MAOA genes in the genetic predisposition to MO, while DDC might confer susceptibility to MA. These results suggest a differential involvement of serotonin-related genes in the genetic background of MO and MA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Dopa Decarboxylase / genetics
  • Epistasis, Genetic
  • Genome-Wide Association Study*
  • Humans
  • Migraine Disorders / genetics*
  • Monoamine Oxidase / genetics
  • Polymorphism, Single Nucleotide
  • Receptor, Serotonin, 5-HT2B / genetics*
  • Serotonin / genetics*
  • Spain


  • Receptor, Serotonin, 5-HT2B
  • Serotonin
  • Monoamine Oxidase
  • Dopa Decarboxylase