Treatment and follow-up of oral dysplasia - a systematic review and meta-analysis

Head Neck. 2009 Dec;31(12):1600-9. doi: 10.1002/hed.21131.


Background: The aim of this study was to inform an evidence-based management policy for oral dysplastic lesions.

Methods: Systematic review was performed with meta-analysis. Studies reporting follow-up of patients with histologically confirmed oral dysplasia were included. Outcome measures included malignant transformation rate (MTR) and time to malignant transformation (TMT). Subgroup analysis was performed by histologic grade, clinical risk factors, and treatment modality. Heterogeneity was assessed.

Results: Fourteen nonrandomized studies, reporting on 992 patients, were included. There was considerable heterogeneity between studies: mean overall MTR = 12.1% (confidence interval: 8.1%, 17.9%) and mean TMT = 4.3 years. Histologic grade significantly affected mean MTR (p < .008). Lesions that were not excised demonstrated considerably higher MTR than those that were excised (p = .003).

Conclusions: Oral dysplasia showed a significant rate of transformation to cancer, which was related to grade and was decreased significantly but not eliminated by excision. This suggested the need for excision and continued surveillance.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Cell Transformation, Neoplastic / pathology*
  • Clinical Trials as Topic
  • Evidence-Based Medicine
  • Female
  • Follow-Up Studies
  • Humans
  • Hyperplasia / pathology
  • Incidence
  • Male
  • Mouth / pathology*
  • Mouth Diseases / pathology
  • Mouth Diseases / therapy
  • Mouth Neoplasms / epidemiology
  • Mouth Neoplasms / pathology*
  • Mouth Neoplasms / surgery
  • Mouth Neoplasms / therapy
  • Precancerous Conditions / pathology*
  • Precancerous Conditions / surgery*
  • Precancerous Conditions / therapy
  • Risk Assessment