A Recent Adaptive Transposable Element Insertion Near Highly Conserved Developmental Loci in Drosophila Melanogaster

Mol Biol Evol. 2009 Sep;26(9):1949-61. doi: 10.1093/molbev/msp107. Epub 2009 May 20.

Abstract

A recent genomewide screen identified 13 transposable elements that are likely to have been adaptive during or after the spread of Drosophila melanogaster out of Africa. One of these insertions, Bari-Juvenile hormone epoxy hydrolase (Bari-Jheh), was associated with the selective sweep of its flanking neutral variation and with reduction of expression of one of its neighboring genes: Jheh3. Here, we provide further evidence that Bari-Jheh insertion is adaptive. We delimit the extent of the selective sweep and show that Bari-Jheh is the only mutation linked to the sweep. Bari-Jheh also lowers the expression of its other flanking gene, Jheh2. Subtle consequences of Bari-Jheh insertion on life-history traits are consistent with the effects of reduced expression of the Jheh genes. Finally, we analyze molecular evolution of Jheh genes in both the long- and the short-term and conclude that Bari-Jheh appears to be a very rare adaptive event in the history of these genes. We discuss the implications of these findings for the detection and understanding of adaptation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alleles
  • Amino Acid Substitution / genetics
  • Animals
  • Base Pairing / genetics
  • Base Sequence
  • Cell Survival
  • Conserved Sequence*
  • DNA Transposable Elements / genetics*
  • DNA, Intergenic / genetics
  • Drosophila melanogaster / genetics*
  • Drosophila melanogaster / growth & development*
  • Evolution, Molecular
  • Gene Expression Regulation
  • Genes, Insect
  • Models, Genetic
  • Molecular Sequence Data
  • Mutagenesis, Insertional / genetics*
  • Mutation / genetics
  • Open Reading Frames / genetics
  • Ovum / cytology
  • Phenotype
  • Polymorphism, Genetic
  • Quantitative Trait Loci / genetics*
  • Selection, Genetic

Substances

  • DNA Transposable Elements
  • DNA, Intergenic

Associated data

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