Biophysical dissection of membrane proteins

Nature. 2009 May 21;459(7245):344-6. doi: 10.1038/nature08142.


The first atomic-resolution structure of a membrane protein was solved in 1985. Twenty-four years and more than 180 unique structures later, what have we have learned? An examination of the atomic details of several diverse membrane proteins reveals some remarkable biophysical features and suggests that we can expect to achieve much more in the decades to come.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Amino Acid Motifs
  • Animals
  • Biophysics
  • Humans
  • Lipid Bilayers / chemistry
  • Lipid Bilayers / metabolism
  • Membrane Proteins / chemistry*
  • Membrane Proteins / metabolism*
  • Protein Structure, Secondary
  • Signal Transduction


  • Lipid Bilayers
  • Membrane Proteins