Combined phylogenetic and neighbourhood analysis of the hexose transporters and glucose sensors in yeasts

FEMS Yeast Res. 2009 Jun;9(4):526-34. doi: 10.1111/j.1567-1364.2009.00511.x. Epub 2009 May 1.


The sugar porter family in yeasts encompasses a wide variety of transporters including the hexose transporters and glucose sensors. We analysed a total of 75 members from both groups in nine hemiascomycetous species, with complete and well-annotated genomes: Saccharomyces cerevisiae, Candida glabrata, Zygosaccharomyces rouxii, Kluyveromyces thermotolerans, Saccharomyces kluyverii, Kluyveromyces lactis, Eremothecium gossypii, Debaryomyces hansenii and Yarrowia lipolytica. We present a model for the evolution of the hexose transporters and glucose sensors, supported by two types of complementary evidences: phylogeny and neighbourhood analysis. Five lineages of evolution were identified and discussed according to different mechanisms of gene evolution: lineage A for HXT1, HXT3, HXT4, HXT5, HXT6 and HXT7; lineage B for HXT2 and HXT10; lineage C for HXT8; lineage D for HXT14; and lineage E for SNF3 and RGT2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ascomycota / genetics*
  • Cluster Analysis
  • Evolution, Molecular
  • Monosaccharide Transport Proteins / genetics*
  • Phylogeny*
  • Receptors, Cell Surface / genetics*
  • Sequence Homology, Amino Acid
  • Yeasts / genetics*


  • Monosaccharide Transport Proteins
  • Receptors, Cell Surface
  • glucose receptor