A prospective randomized study to assess the efficacy of rate and site of atrial pacing on long-term development of atrial fibrillation

J Cardiovasc Electrophysiol. 2009 Sep;20(9):1020-5. doi: 10.1111/j.1540-8167.2009.01484.x. Epub 2009 May 4.


The Septal Pacing for Atrial Fibrillation Suppression Evaluation (SAFE) study is a single-blinded, parallel randomized designed multicenter study in pacemaker indicated patients with paroxysmal atrial fibrillation (AF). The objective is to evaluate whether the site of atrial pacing--conventional right atrial appendage versus low atrial septal--with or without atrial overdrive pacing will influence the development of persistent AF. The study will provide a definitive answer to whether a different atrial pacing site or the use of AF suppression pacing or both can give incremental antiarrhythmic benefit when one is implanting a device for a patient with a history of paroxysmal AF.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Atrial Fibrillation / mortality*
  • Atrial Fibrillation / prevention & control*
  • Cardiac Pacing, Artificial / methods*
  • Cardiac Pacing, Artificial / mortality*
  • Humans
  • Internationality
  • Prospective Studies
  • Survival Analysis
  • Survival Rate
  • Treatment Outcome