Metastatic Merkel cell carcinoma with positive expression of thyroid transcription factor-1--a case report

Am J Dermatopathol. 2009 Jun;31(4):384-6. doi: 10.1097/DAD.0b013e31819821e8.

Abstract

We report on a case of metastatic Merkel cell carcinoma in a 74-year-old patient with positive staining for thyroid transcription factor-1. This represents a new immunohistochemical staining pattern for Merkel cell carcinoma and has implications regarding the accurate diagnosis of this tumor type.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biomarkers, Tumor / metabolism
  • Biopsy
  • Carcinoma, Merkel Cell / metabolism*
  • Carcinoma, Merkel Cell / pathology*
  • Female
  • Humans
  • Immunohistochemistry
  • Nuclear Proteins / metabolism*
  • Skin Neoplasms / metabolism*
  • Skin Neoplasms / pathology*
  • Thyroid Nuclear Factor 1
  • Transcription Factors / metabolism*

Substances

  • Biomarkers, Tumor
  • NKX2-1 protein, human
  • Nuclear Proteins
  • Thyroid Nuclear Factor 1
  • Transcription Factors