Antioxidant action of propofol on liver microsomes, mitochondria and brain synaptosomes in the rat

E Musacchio; V Rizzoli; M Bianchi; A Bindoli; L Galzigna

doi:10.1111/j.1600-0773.1991.tb00414.x

Antioxidant action of propofol on liver microsomes, mitochondria and brain synaptosomes in the rat

Pharmacol Toxicol. 1991 Jul;69(1):75-7. doi: 10.1111/j.1600-0773.1991.tb00414.x.

Authors

E Musacchio¹, V Rizzoli, M Bianchi, A Bindoli, L Galzigna

Affiliation

¹ Department of Biological Chemistry, University of Padova, Italy.

PMID: 1946196
DOI: 10.1111/j.1600-0773.1991.tb00414.x

Abstract

2,6-Diisopropylphenol (propofol), a new intravenous anaesthetic, has a structure similar to that of butylated hydroxytoluene (BHT). Both compounds inhibit the production of malondialdehyde (MDA) in rat liver mitochondria and microsomes as well as in rat brain synaptosomes treated with lipid peroxidation inducers.

MeSH terms

Animals
Antioxidants / pharmacology*
Ascorbic Acid / pharmacology
Benzene Derivatives / pharmacology
Brain Chemistry / drug effects
Butylated Hydroxytoluene / pharmacology
Electron Transport / drug effects
In Vitro Techniques
Iron / pharmacology
Lipid Peroxidation / drug effects
Male
Malondialdehyde / metabolism
Microsomes, Liver / drug effects
Microsomes, Liver / metabolism*
Mitochondria, Liver / drug effects
Mitochondria, Liver / metabolism*
Propofol / pharmacology*
Rats
Rats, Inbred Strains
Synaptosomes / drug effects
Synaptosomes / metabolism*

Substances

Antioxidants
Benzene Derivatives
Butylated Hydroxytoluene
Malondialdehyde
Iron
cumene hydroperoxide
Ascorbic Acid
Propofol