Fetal and postnatal growth and blood pressure at the age of 2 years. The Generation R Study

J Hypertens. 2009 Jun;27(6):1152-7. doi: 10.1097/hjh.0b013e3283299973.


Objectives: To examine which fetal and postnatal growth characteristics are associated with blood pressure (BP) in children at the age of 2 years.

Methods: This study was embedded in the Generation R Study, a population-based prospective cohort study from early fetal life onwards. Fetal ultrasound examinations were carried out at the visits in one of the research centers in early, mid- and late pregnancy. Fetal femur length standard deviation scores (SDS) were used as a proxy for body length SDS in the prenatal data. BP measurements were performed at the age of 2 years. Analyses were performed in 566 children.

Results: Inverse tendencies for fetal femur length and estimated fetal weight in mid-pregnancy and late pregnancy with SBP at the age of 2 years were found. The association was only significant for femur length in late pregnancy [-1.22 {95% confidence interval (CI), -2.09, -0.34} mmHg/femur length SDS score]. Length change from late pregnancy to the age of 2 years was positively associated with SBP and DBP [0.97 (95% CI, 0.27, 1.66) mmHg and 0.82 (95% CI, 0.09, 1.55) mmHg per SDS length change, respectively]. A similar association between weight change and SBP was found.

Conclusion: Increased skeletal and nonskeletal growth rates from late pregnancy to the age of 2 years are associated with somewhat higher SBP and DBP in early childhood. Replication of these findings and studies examining the underlying biological pathways and the long-term consequences are needed.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Blood Pressure / physiology*
  • Body Height
  • Child Development / physiology*
  • Child, Preschool
  • Cohort Studies
  • Female
  • Femur / diagnostic imaging
  • Femur / embryology
  • Fetal Development / physiology*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Pregnancy
  • Prospective Studies
  • Ultrasonography, Prenatal