Preclinical and clinical studies of anticancer agent-incorporating polymer micelles

Cancer Sci. 2009 Apr;100(4):572-9. doi: 10.1111/j.1349-7006.2009.01103.x.

Abstract

The size of anticancer agent-incorporating micelles can be controlled within the diameter range of 20-100 nm to ensure that they do not penetrate normal vessel walls. With this development, it is expected that the incidence of drug-induced side-effects may be decreased owing to the reduced drug distribution in normal tissue. Micelle systems can also evade non-specific capture by the reticuloendothelial system because the outer shell of a micelle is covered with polyethylene glycol. Consequently, a polymer micelle carrier can be delivered selectively to a tumor by utilizing the enhanced permeability and retention effect. Moreover, a water-insoluble drug can be incorporated into polymer micelles. Presently, several anticancer agent-incorporating micelle carrier systems are under preclinical and clinical evaluation. Furthermore, nucleic acid-incorporating micelle carrier systems are also being developed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / administration & dosage
  • Antibiotics, Antineoplastic / pharmacology
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents, Phytogenic / administration & dosage
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Clinical Trials as Topic
  • Doxorubicin / administration & dosage
  • Doxorubicin / pharmacology
  • Drug Carriers / chemistry
  • Drug Delivery Systems
  • Drug Evaluation, Preclinical
  • Humans
  • Micelles*
  • Nanoparticles / chemistry
  • Paclitaxel / administration & dosage
  • Paclitaxel / analogs & derivatives
  • Paclitaxel / pharmacology
  • Particle Size
  • Polyethylene Glycols / chemistry
  • Polymers / chemistry*
  • Zinostatin / administration & dosage
  • Zinostatin / pharmacology

Substances

  • Antibiotics, Antineoplastic
  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Drug Carriers
  • Micelles
  • NK105
  • Polymers
  • Polyethylene Glycols
  • Doxorubicin
  • Zinostatin
  • Paclitaxel