Sequence analysis of firefly luciferase family reveals a conservative sequence motif

Protein Seq Data Anal. 1991 Aug;4(2):111-7.


A conservative sequence motif was extracted from an alignment of the firefly luciferase family. AngR derived from a pathogenic bacterium and acetyl-CoA synthetases derived from two ascomycete fungi were identified as members of the firefly luciferase family by a homology search with the motif and other sequence comparison analyses. The motif sequence shares several characteristics with the phosphate-binding sites of phosphoproteins and nucleotide-binding proteins. A multiple alignment and an unrooted phylogenetic tree were constructed for the investigation of evolutionary relationships within the firefly luciferase family.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biological Evolution
  • Coleoptera / chemistry
  • Luciferases / chemistry*
  • Molecular Sequence Data
  • Phylogeny
  • Sequence Alignment
  • Structure-Activity Relationship


  • Luciferases