Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes

Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9717-21. doi: 10.1073/pnas.88.21.9717.

Abstract

We have identified three polymorphic microsatellites (which we call TNFa, TNFb, and TNFc) within a 12-kilobase region of the human major histocompatibility complex (MHC) that includes the tumor necrosis factor (TNF) locus. TNFc is located within the first intron of the TNF-beta gene and has only 2 alleles. TNFa and TNFb are 3.5 kilobases upstream (telomeric) of the TNF-beta gene and have at least 13 and 7 alleles, respectively. TNFa, -b, and -c alleles are in linkage disequilibrium with alleles at other loci within the MHC, including class I, class II, and class III. TNFa, -b, and -c alleles are also associated with extended HLA haplotypes. These TNF polymorphisms will allow a thorough genetic analysis of the involvement of TNF in MHC-linked pathologies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Gene Frequency
  • Genetic Linkage
  • HLA Antigens / genetics*
  • Haplotypes
  • Humans
  • Major Histocompatibility Complex*
  • Molecular Sequence Data
  • Oligonucleotides / chemistry
  • Polymorphism, Genetic*
  • Repetitive Sequences, Nucleic Acid
  • Tumor Necrosis Factor-alpha / genetics*

Substances

  • HLA Antigens
  • Oligonucleotides
  • Tumor Necrosis Factor-alpha