Differences in the immune response to hepatitis B and Haemophilus influenzae type b vaccines in Guatemalan infants by ethnic group and nutritional status

Vaccine. 2009 Jun 2;27(27):3650-4. doi: 10.1016/j.vaccine.2009.03.035. Epub 2009 Apr 7.


Ladino and native Indian Guatemalan infants developed high rates (96-100%) of protective antibodies after receiving conjugate Haemophilus influenzae type b and hepatitis B vaccines at 2, 4 and 6 months of age. Native Indian infants developed significantly (p<0.01) higher geometric mean anti-PRP (polyribose-ribitol-phosphate) and anti-HBs (anti-hepatitis b surface) antibody concentrations than Ladino infants. Malnourished infants generally responded as well as healthy infants. Unvaccinated native Indian infants had higher rates of developing anti-PRP antibodies than Ladino infants by seven months of age.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Bacterial / blood*
  • Bacterial Capsules / adverse effects
  • Bacterial Capsules / immunology*
  • Guatemala / ethnology
  • Haemophilus Vaccines / adverse effects
  • Haemophilus Vaccines / immunology*
  • Hepatitis B Antibodies / blood*
  • Hepatitis B Vaccines / adverse effects
  • Hepatitis B Vaccines / immunology*
  • Humans
  • Infant
  • Malnutrition / immunology*


  • Antibodies, Bacterial
  • Haemophilus Vaccines
  • Haemophilus influenzae type b polysaccharide vaccine
  • Hepatitis B Antibodies
  • Hepatitis B Vaccines