No evidence of association of FLJ10986 and ITPR2 with ALS in a large German cohort

Neurobiol Aging. 2011 Mar;32(3):551.e1-4. doi: 10.1016/j.neurobiolaging.2009.04.018. Epub 2009 May 22.


A recent genome-wide association study (GWAS) found significant association of six single nucleotide polymorphisms (SNPs) in the gene FLJ10986 with sporadic amyotrophic lateral sclerosis (SALS). Another independent GWAS reported significant association of one SNP in the gene inositol 1,4,5-triphosphate receptor 2 (ITPR2) with SALS. These studies provided conflicting results. We examined the six most significant SNPs in FLJ10986 and one SNP in ITPR2 in a large cohort consisting of 595 SALS cases and 681 controls ascertained from Germany. Our results did not provide evidence for the association of these SNPs with SALS, suggesting a possible population-specific effect for FLJ10986 and ITPR2 that do not modulate the risk for SALS in the German population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Amyotrophic Lateral Sclerosis / genetics*
  • Cohort Studies
  • Female
  • Genome-Wide Association Study
  • Germany / epidemiology
  • Humans
  • Inositol 1,4,5-Trisphosphate Receptors / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics*
  • Proteins / genetics*


  • FGGY protein, human
  • ITPR2 protein, human
  • Inositol 1,4,5-Trisphosphate Receptors
  • Proteins