Does metabolic syndrome have an impact on the quality of life and mood of hemodialysis patients?

J Ren Nutr. 2009 Sep;19(5):365-71. doi: 10.1053/j.jrn.2009.01.016. Epub 2009 May 23.

Abstract

Objective: Little is known about the association between metabolic syndrome (MetSyn), health-related quality of life (HRQoL), and depressive symptoms in hemodialysis (HD) patients. We hypothesized that MetSyn may be associated with lower HRQoL and depression in HD patients.

Design: This was a cross-sectional study.

Setting: The trial involved HD patients at a tertiary-care hospital.

Patients: We evaluated 115 patients (41 women and 74 men; mean age, 48.4 +/- SD 11.9 years SD).

Methods: MetSyn was defined according to National Cholesterol Education Panel criteria. The Medical Outcomes Study Short Form-36 (SF-36) and Beck Depression Inventory (BDI) were used to assess HRQoL and signs of depression, respectively. We compared HRQoL and clinical and psychosocial characteristics among participants with and without MetSyn.

Results: Fifty patients (43.5%) had MetSyn, and 65 patients (56.5%) were free of MetSyn. Comparisons of SF-36 and BDI scores between HD patients with and without MetSyn revealed no statistically significant differences. The Physical Component Summary Score (PCS) of SF-36 was independently associated with HD duration (beta = -0.274, P = .002), age (beta = -0.206, P = .024), sleep disturbance (beta = -0.175, P = .045), albumin (beta = +0.252, P = .006), and hemoglobin (beta = +0.270, P = .002) in stepwise linear regression analysis. The MetSyn was not associated with PCS. The Mental Component Summary Score of SF-36 was independently associated with hemoglobin (beta = +0.235, P = .016) and BDI score (beta = -0.218, P = .025).

Conclusions: The presence of MetSyn was not associated with HRQoL according to the Mental Component Summary Score. In HD patients, HRQoL and depressive behaviors were not influenced by MetSyn, but by various other factors.

MeSH terms

  • Adult
  • Blood Glucose / analysis
  • Creatinine / blood
  • Cross-Sectional Studies
  • Depression / epidemiology
  • Depression / etiology*
  • Female
  • Hemoglobins / analysis
  • Humans
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / psychology
  • Kidney Failure, Chronic / therapy*
  • Linear Models
  • Male
  • Metabolic Syndrome / complications*
  • Metabolic Syndrome / epidemiology
  • Metabolic Syndrome / psychology*
  • Middle Aged
  • Quality of Life*
  • Renal Dialysis / mortality
  • Renal Dialysis / psychology*
  • Serum Albumin / analysis
  • Time Factors
  • Turkey / epidemiology

Substances

  • Blood Glucose
  • Hemoglobins
  • Serum Albumin
  • Creatinine