Pharmacokinetic investigation of increased efficacy against malignant gliomas of carboplatin combined with hyperbaric oxygenation

Neurol Med Chir (Tokyo). 2009 May;49(5):193-7; discussion 197. doi: 10.2176/nmc.49.193.

Abstract

The efficacy of intravenous administration of 400 mg carboplatin/m(2) body surface area over 60 minutes combined with hyperbaric oxygenation (HBO) therapy (0.2 MPa for 60 min) was investigated in 6 Japanese patients (aged 36-67 years) with malignant or brainstem gliomas. Plasma ultra-filtrate samples were analyzed by high-performance liquid chromatography to evaluate the relationship between efficacy and pharmacokinetics. Brain tumor response was evaluated by magnetic resonance imaging as a function of maximum plasma concentration, area under the curve, or mean residence time (MRT) for carboplatin. The MRT for carboplatin in the complete or partial response group (mean +/- standard deviation 4.3 +/- 1.7 hrs; 6 courses in 3 patients) was significantly longer (p < 0.05) than that in the progressive disease group (2.4 +/- 0.1 hrs; 3 courses in 3 patients), but maximum plasma concentration and area under the curve showed no differences. These results suggest that HBO therapy prolongs the biological residence time of carboplatin. MRT for carboplatin may be useful for predicting continuation or modification of chemotherapy and/or clinical antitumor effects in patients with malignant gliomas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents, Alkylating / administration & dosage
  • Antineoplastic Agents, Alkylating / pharmacokinetics
  • Antineoplastic Agents, Alkylating / therapeutic use*
  • Astrocytoma / drug therapy
  • Astrocytoma / radiotherapy
  • Astrocytoma / surgery
  • Astrocytoma / therapy
  • Brain Neoplasms / drug therapy
  • Brain Neoplasms / radiotherapy
  • Brain Neoplasms / surgery
  • Brain Neoplasms / therapy*
  • Brain Stem Neoplasms / drug therapy
  • Brain Stem Neoplasms / radiotherapy
  • Brain Stem Neoplasms / surgery
  • Brain Stem Neoplasms / therapy
  • Carboplatin / administration & dosage
  • Carboplatin / pharmacokinetics
  • Carboplatin / therapeutic use*
  • Chromatography, High Pressure Liquid
  • Combined Modality Therapy
  • Cranial Irradiation
  • Drug Synergism
  • Female
  • Glioblastoma / drug therapy
  • Glioblastoma / radiotherapy
  • Glioblastoma / surgery
  • Glioblastoma / therapy*
  • Humans
  • Hyperbaric Oxygenation*
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / drug therapy
  • Neoplasm Recurrence, Local / therapy
  • Salvage Therapy
  • Treatment Outcome

Substances

  • Antineoplastic Agents, Alkylating
  • Carboplatin