Fungal keratitis associated with ocular rosacea

Int Ophthalmol. 2010 Jun;30(3):239-44. doi: 10.1007/s10792-009-9311-1. Epub 2009 May 23.


In order to report fungal keratitis in patients of ocular rosacea, a retrospective review of all cases of fungal keratitis was undertaken. Cases in which ocular rosacea coexisted were identified and included in the study. The clinical course of patients thus identified was studied from the medical records and outcomes were evaluated. A total of three cases of fungal keratitis with coexisting ocular rosacea were identified. All three patients were known cases of acne rosacea with an intermittent, irregular treatment for the same. Previous history of contact lens use, ocular surgery or trauma was not present in any of the cases. Microbiological evaluation revealed Aspergillus flavus as the causative organism in two patients and an unidentified hyaline fungus in the third. Patients received simultaneous therapy for fungal keratitis and ocular rosacea. The ocular surface completely stabilized and the infiltrate resolved in all three cases. The chronic ocular surface changes and induced inflammation in ocular rosacea, along with the instillation of topical steroids for therapy, may create an environmental milieu favorable for fungal keratitis. Microbiological evaluation should be considered, even in cases of suspected sterile keratitis, prior to treatment with topical steroids, so as to prevent the possible worsening of an associated infective corneal condition.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aspergillosis / drug therapy
  • Aspergillosis / surgery
  • Aspergillus flavus / isolation & purification
  • Aza Compounds / therapeutic use
  • Doxycycline / therapeutic use
  • Eye Infections, Fungal / drug therapy*
  • Eye Infections, Fungal / surgery
  • Female
  • Fluoroquinolones
  • Humans
  • Keratitis / drug therapy
  • Keratitis / microbiology*
  • Keratitis / surgery
  • Male
  • Middle Aged
  • Moxifloxacin
  • Photophobia / etiology
  • Quinolines / therapeutic use
  • Rosacea / drug therapy
  • Rosacea / microbiology*
  • Rosacea / surgery
  • Visual Acuity
  • Young Adult


  • Aza Compounds
  • Fluoroquinolones
  • Quinolines
  • Doxycycline
  • Moxifloxacin