Developmentally regulated cyclic AMP-dependent protein kinases in Dictyostelium discoideum

Cell. 1977 May;11(1):173-80. doi: 10.1016/0092-8674(77)90328-2.


Two apparently distinct species of cyclic AMP-dependent protein kinase appear during the first 1-2 hr of development in Dictyostelium discoideum; no such activity can be detected in vegetative cell extracts. These two kinases are similar in properties to the type I and II cyclic AMP-dependent protein kinases found in a number of mammalian tissues. Their time of appearance supports the idea that one or both mediate the effects of cyclic AMP on gene expression early in Dictyostelium development.

MeSH terms

  • Cell Extracts / metabolism
  • Cyclic AMP / metabolism
  • Dictyostelium / enzymology*
  • Dictyostelium / growth & development
  • Isoenzymes / biosynthesis*
  • Isoenzymes / metabolism
  • Myxomycetes / enzymology*
  • Protein Kinases / biosynthesis*
  • Protein Kinases / metabolism


  • Cell Extracts
  • Isoenzymes
  • Cyclic AMP
  • Protein Kinases