Tonotopic reorganization of developing auditory brainstem circuits

Nat Neurosci. 2009 Jun;12(6):711-7. doi: 10.1038/nn.2332. Epub 2009 May 10.


A fundamental organizing principle of auditory brain circuits is tonotopy, the orderly representation of the sound frequency to which neurons are most sensitive. Tonotopy arises from the coding of frequency along the cochlea and the topographic organization of auditory pathways. The mechanisms that underlie the establishment of tonotopy are poorly understood. In auditory brainstem pathways, topographic precision is present at very early stages in development, which may suggest that synaptic reorganization contributes little to the construction of precise tonotopic maps. Accumulating evidence from several brainstem nuclei, however, is now changing this view by demonstrating that developing auditory brainstem circuits undergo a marked degree of refinement on both a subcellular and circuit level.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Auditory Pathways / anatomy & histology
  • Auditory Pathways / growth & development*
  • Axons / physiology
  • Axons / ultrastructure
  • Brain Stem / anatomy & histology
  • Brain Stem / growth & development*
  • Cochlea / anatomy & histology
  • Cochlea / physiology
  • Humans
  • Neuronal Plasticity / physiology*
  • Olivary Nucleus / anatomy & histology
  • Olivary Nucleus / growth & development
  • Pitch Perception / physiology