Interleukin 17 production among patients with American cutaneous leishmaniasis

J Infect Dis. 2009 Jul 1;200(1):75-8. doi: 10.1086/599380.


Interleukin 17 (IL-17) plays a critical role in inflammation and autoimmunity. Very little is known about IL-17 in protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis and cutaneous leishmaniasis produce higher levels of IL-17 than do lymphocytes obtained from uninfected control subjects (P<.01). There was a tendency for tissue obtained from patients with mucosal leishmaniasis to contain a higher number of cells expressing IL-17, compared with tissue obtained from patients with cutaneous leishmaniasis, and there was a direct correlation between the number of cells expressing IL-17 and the presence of cellular inflammation at the lesion site (r2 = 0.86; P<.001) These data support the role of IL-17 in the pathogenesis of the inflammatory reaction in leishmaniasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoimmunity
  • Humans
  • Inflammation / immunology
  • Interleukin-17 / genetics*
  • Leishmaniasis, Mucocutaneous / genetics
  • Leishmaniasis, Mucocutaneous / immunology*
  • Lymphocyte Activation / genetics
  • Lymphocyte Activation / immunology
  • Lymphocytes / immunology*
  • Reference Values
  • Th1 Cells / immunology


  • Interleukin-17