Telomere uncapping, chromosomes, and carcinomas

Cancer Cell. 2009 Jun 2;15(6):455-7. doi: 10.1016/j.ccr.2009.05.006.

Abstract

Data from mouse models and from human cancers have supported the idea that telomere shortening leads to chromosomal instability and epithelial carcinogenesis. In this issue of Cancer Cell, Else et al. demonstrate that telomere uncapping-altering a protein that protects chromosome ends without shortening telomeres-also results in epithelial cancers.

Publication types

  • Comment

MeSH terms

  • Animals
  • Carcinoma / metabolism*
  • Carcinoma / pathology
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Neoplastic / metabolism*
  • Cell Transformation, Neoplastic / pathology
  • Chromosomal Instability / genetics
  • Chromosomal Instability / physiology
  • Lymphoma / metabolism
  • Lymphoma / pathology
  • Mice
  • Mice, Transgenic
  • Phenotype
  • Sarcoma / metabolism
  • Sarcoma / pathology
  • Skin Neoplasms / metabolism*
  • Skin Neoplasms / pathology
  • Telomere / genetics
  • Telomere / physiology*
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / physiology*

Substances

  • Tumor Suppressor Protein p53