Abstract
Data from mouse models and from human cancers have supported the idea that telomere shortening leads to chromosomal instability and epithelial carcinogenesis. In this issue of Cancer Cell, Else et al. demonstrate that telomere uncapping-altering a protein that protects chromosome ends without shortening telomeres-also results in epithelial cancers.
MeSH terms
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Animals
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Carcinoma / metabolism*
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Carcinoma / pathology
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Cell Transformation, Neoplastic / genetics
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Cell Transformation, Neoplastic / metabolism*
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Cell Transformation, Neoplastic / pathology
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Chromosomal Instability / genetics
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Chromosomal Instability / physiology
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Lymphoma / metabolism
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Lymphoma / pathology
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Mice
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Mice, Transgenic
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Phenotype
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Sarcoma / metabolism
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Sarcoma / pathology
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Skin Neoplasms / metabolism*
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Skin Neoplasms / pathology
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Telomere / genetics
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Telomere / physiology*
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Tumor Suppressor Protein p53 / genetics
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Tumor Suppressor Protein p53 / physiology*
Substances
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Tumor Suppressor Protein p53