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. 2009 Jun;196(2):195-204.
doi: 10.1007/s00221-009-1836-z. Epub 2009 May 29.

Ipsilesional Trajectory Control Is Related to Contralesional Arm Paralysis After Left Hemisphere Damage

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Free PMC article

Ipsilesional Trajectory Control Is Related to Contralesional Arm Paralysis After Left Hemisphere Damage

Kathleen Y Haaland et al. Exp Brain Res. .
Free PMC article

Abstract

We have recently shown ipsilateral dynamic deficits in trajectory control are present in left hemisphere damaged (LHD) patients with paresis, as evidenced by impaired modulation of torque amplitude as response amplitude increases. The purpose of the current study is to determine if these ipsilateral deficits are more common with contralateral hemiparesis and greater damage to the motor system, as evidenced by structural imaging. Three groups of right-handed subjects (healthy controls, LHD stroke patients with and without upper extremity paresis) performed single-joint elbow movements of varying amplitudes with their left arm in the left hemispace. Only the paretic group demonstrated dynamic deficits characterized by decreased modulation of peak torque (reflected by peak acceleration changes) as response amplitude increased. These results could not be attributed to lesion volume or peak velocity as neither variable differed across the groups. However, the paretic group had damage to a larger number of areas within the motor system than the non-paretic group suggesting that such damage increases the probability of ipsilesional deficits in dynamic control for modulating torque amplitude after left hemisphere damage.

Figures

Fig. 1
Fig. 1
a Average tangential velocity profiles and b average tangential acceleration profiles for each target for a representative subject from each group. c Mean peak velocity, peak acceleration (normalized to % max) and acceleration duration for each target is displayed for the three groups. Bars indicate standard error of the mean
Fig. 2
Fig. 2
Lesion locations were based upon superimposing lesion tracings from MRI or CT images on axial slices for left hemisphere damaged stroke patients a with upper extremity paresis and b without upper extremity paresis. Colors of shaded regions denote percentage (20, 40, 60, 80, or 100%) of patients with lesion in the corresponding area. Tic marks the central sulcus

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