Antisecretory factor-inducing therapy improves the clinical outcome in patients with Ménière's disease

Acta Otolaryngol. 2010 Feb;130(2):223-7. doi: 10.3109/00016480903022842.


Conclusion: Intake of antisecretory factor (AF)-inducing SPC-flakes significantly reduced vertigo in patients suffering from Ménière's disease (MD). The positive effect may be due to a modulation of the transport of water and ions in the endolymphatic space.

Objective: To evaluate the effects of a 3-month treatment period with SPC-flakes in patients suffering from MD.

Patients and methods: A prospective, double-blind, placebo-controlled study was performed. A total of 51 adult patients with MD were included in the study: 27 subjects treated with SPC-flakes and 24 subjects with control cereals. The patients received SPC-flakes or control cereals (1 g per kg body weight per 24 h in two servings) for 3 months. Otoneurological examinations were carried out before and after this period.

Results: The severity of MD was classified according to the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) grading system. Fourteen of the 27 patients randomized to intake of the AF-inducing SPC-flakes reported decreased vertigo, compared with 2 of 24 in the control group (p < 0.001). No consistent change in the otoneurological examinations could be demonstrated in any of the groups of patients.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Cochlea / metabolism
  • Cochlea / physiopathology
  • Double-Blind Method
  • Edible Grain*
  • Endolymphatic Sac / metabolism
  • Endolymphatic Sac / physiopathology
  • Female
  • Humans
  • Male
  • Meniere Disease / diet therapy*
  • Meniere Disease / metabolism
  • Meniere Disease / physiopathology
  • Middle Aged
  • Neuropeptides / metabolism*
  • Prospective Studies
  • Vertigo / metabolism
  • Vertigo / physiopathology
  • Vertigo / therapy


  • Neuropeptides
  • antisecretory factor