Is there a specific mutation of p53 gene due to radon exposure? A systematic review

Int J Radiat Biol. 2009 Jul;85(7):614-21. doi: 10.1080/09553000902954504.


Purpose: To review the existing literature analysing the influence of radon exposure on mutations in tumour protein 53 gene (TP53) in lung cancer patients.

Material and methods: Medline and EMBASE databases along with the International Agency for Research on Cancer (IARC) monographies were revised. Studies that had radon concentration as exposure variable and TP53 mutations as a result variable were included.

Results: Eight studies were obtained, with a total of 578 individuals. They had been carried out on miners and on general population. A 26% of the miners' tumours had a mutation in gene TP53, versus a 24% in the population exposed to residential radon. A predominance of the AGG(ARG)--> ATG(MET) (Arginine to Methionine) mutation in miners was observed.

Conclusions: The available results are not consistent in order to support the existence of a radon hotspot in TP53 gene. Future research should focus at least on exons 5 to 8, where most of the mutation clusters in lung tumours are observed.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Codon
  • Exons
  • Genes, p53*
  • Humans
  • Lung Neoplasms / genetics*
  • Mutation*
  • Neoplasms, Radiation-Induced / genetics*
  • Radon / adverse effects*
  • Smoking / adverse effects


  • Codon
  • Radon