Abstract
CD34 is a cell-surface sialomucin widely used for hematopoietic stem cell purification and as a marker of most vascular endothelial cells, including those of capillaries in the majority of tissues. Surprisingly, despite extensive research, the function of this sialomucin has remained elusive, with proposed roles ranging from enhancing proliferation or inhibiting differentiation to acting as a proadhesive L-selectin ligand. Here, we review our recent studies, which suggest that CD34 does, indeed, play a role in leukocyte and HSC trafficking, but that this is through its action as a regulated blocker of cell adhesion and enhancer of migration.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigens, CD34 / chemistry
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Antigens, CD34 / genetics
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Antigens, CD34 / physiology*
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Asthma / etiology
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Biomarkers
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Bone Marrow Cells / cytology
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Bone Marrow Cells / immunology
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Bone Marrow Cells / physiology
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Cell Adhesion / immunology
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Cell Adhesion / physiology
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Cell Differentiation / immunology
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Cell Differentiation / physiology
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Cell Movement / immunology
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Cell Movement / physiology
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Colonic Neoplasms / etiology
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Endothelial Cells / cytology
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Endothelial Cells / immunology
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Endothelial Cells / physiology
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Hematopoietic Stem Cells / cytology
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Hematopoietic Stem Cells / immunology
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Hematopoietic Stem Cells / physiology*
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Humans
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Mast Cells / cytology
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Mast Cells / immunology
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Mast Cells / physiology
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Mice
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Microcirculation / immunology
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Microcirculation / physiology
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Models, Biological
Substances
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Antigens, CD34
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Biomarkers