Abstract
The production and functional activity of two important white blood cells, the granulocytes and macrophages, are regulated mainly by a group of glycoprotein colony-stimulating factors. The colony-stimulating factors have been mass-produced with recombinant technology and are now proving of value in preventing or suppressing infections in a variety of individuals with subnormal or defective formation of blood cells.
MeSH terms
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Acquired Immunodeficiency Syndrome / therapy
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Anemia, Aplastic / therapy
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Animals
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Colony-Stimulating Factors / genetics
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Colony-Stimulating Factors / physiology*
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Colony-Stimulating Factors / therapeutic use
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Granulocytes / cytology
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Granulocytes / physiology*
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Hematopoiesis
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Hematopoietic Stem Cells / cytology
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Hematopoietic Stem Cells / physiology*
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Humans
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Macrophages / cytology
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Macrophages / physiology*
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Mice
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Neoplasms / therapy
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Neutropenia / therapy
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Recombinant Proteins / therapeutic use
Substances
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Colony-Stimulating Factors
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Recombinant Proteins