Control of granulocytes and macrophages: molecular, cellular, and clinical aspects

Science. 1991 Oct 25;254(5031):529-33. doi: 10.1126/science.1948028.

Abstract

The production and functional activity of two important white blood cells, the granulocytes and macrophages, are regulated mainly by a group of glycoprotein colony-stimulating factors. The colony-stimulating factors have been mass-produced with recombinant technology and are now proving of value in preventing or suppressing infections in a variety of individuals with subnormal or defective formation of blood cells.

Publication types

  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / therapy
  • Anemia, Aplastic / therapy
  • Animals
  • Colony-Stimulating Factors / genetics
  • Colony-Stimulating Factors / physiology*
  • Colony-Stimulating Factors / therapeutic use
  • Granulocytes / cytology
  • Granulocytes / physiology*
  • Hematopoiesis
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / physiology*
  • Humans
  • Macrophages / cytology
  • Macrophages / physiology*
  • Mice
  • Neoplasms / therapy
  • Neutropenia / therapy
  • Recombinant Proteins / therapeutic use

Substances

  • Colony-Stimulating Factors
  • Recombinant Proteins