Cutaneous metastases of malignant melanoma--how difficult can it be?

Rom J Intern Med. 2008;46(4):375-8.


Malignant melanoma is one of the most aggressive skin neoplasms with histopathological-based therapeutic approach. Unfortunately, in some cases, even the elementary issue of dealing with a primary or metastatic lesion may be sometimes incredible difficult to settle. We studied 11 cases of malignant melanomas that required careful histopathological and immunohistochemical analysis to differentiate between primary and secondary tumor. We evaluated epidermotropism of primary MM including synchronous tumors, local recurrences and metastases.

MeSH terms

  • Diagnosis, Differential
  • Humans
  • Immunohistochemistry
  • Melanoma / diagnosis
  • Melanoma / secondary*
  • Neoplasms, Multiple Primary / diagnosis
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / secondary*