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Comparative Study
, 254 (5031), 578-9

Cloning and Expression of a Cocaine-Sensitive Rat Dopamine Transporter

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Comparative Study

Cloning and Expression of a Cocaine-Sensitive Rat Dopamine Transporter

J E Kilty et al. Science.

Abstract

The action of dopamine and other monoamine neurotransmitters at synapses is terminated predominantly by high-affinity reuptake into presynaptic terminals by specific sodium-dependent neurotransmitter transport proteins. A complementary DNA encoding a rat dopamine transporter has been isolated that exhibits high sequence similarity with the previously cloned norepinephrine and gamma-aminobutyric acid transporters. Transient expression of the complementary DNA in HeLa cells confirms the cocaine sensitivity of this transporter.

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