A perspective: metatranscriptomics as a tool for the discovery of novel biocatalysts

J Biotechnol. 2009 Jun 1;142(1):91-5. doi: 10.1016/j.jbiotec.2009.03.022. Epub 2009 Apr 9.


In this mini-review, advantages and current bottlenecks of metatranscriptomic-sequencing for the discovery of novel enzymes for biotechnological applications will be discussed. Comparison of this innovative approach to traditional metagenomic-sequencing will illustrate that expression profiling has a promising future as a direct and very efficient method for the discovery of novel biocatalysts, even from complex microbial communities.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Archaea / enzymology*
  • Archaea / genetics
  • Bacteria / enzymology*
  • Bacteria / genetics
  • Biocatalysis*
  • Enzymes / metabolism*
  • Gene Expression Profiling*
  • Genome, Archaeal
  • Genome, Bacterial
  • Genomics / methods*
  • Sequence Analysis, DNA


  • Enzymes