Motion correction of multi-frame PET data in neuroreceptor mapping: simulation based validation

Neuroimage. 2009 Oct 1;47(4):1496-505. doi: 10.1016/j.neuroimage.2009.05.052. Epub 2009 May 27.


Patient motion during positron emission tomography scanning can affect the accuracy of the data analysis in two ways: 1) movement occurring during emission data acquisition alters the time activity curves (TACs), measured at a voxel or region of interest (ROI), and hence introduces errors in the parameter estimates derived from kinetic modeling; 2) emission-transmission mismatches introduce errors during attenuation and scatter correction, and hence in the radioactivity distribution estimates for each time frame of the scan. With the aim of designing an algorithm-based frame realignment method, we first conducted investigations that aimed at optimizing the parameters of a coregistration method, such as the choice of the target volume and the similarity criterion. Based on these results we designed a novel frame realignment strategy in a multi-step algorithm using uncorrected reconstructed images, cross-correlation similarity criteria for the determination of inter-frame motion parameters and emission-transmission mismatch for each frame. Features and validation results are reported here based on a multi-subject simulated [(11)C]raclopride dynamic PET scan database incorporating intra-frame movements of various magnitudes and with various times of occurrence. Performances of the proposed algorithm were evaluated at regional and voxel-based level for binding potential parametric images.

Publication types

  • Evaluation Study
  • Validation Study

MeSH terms

  • Artifacts*
  • Brain / diagnostic imaging
  • Brain / metabolism*
  • Computer Simulation
  • Gene Expression Profiling / methods
  • Humans
  • Image Enhancement / methods*
  • Models, Neurological*
  • Motion
  • Positron-Emission Tomography / methods*
  • Raclopride / pharmacokinetics*
  • Radiopharmaceuticals / pharmacokinetics
  • Receptors, Dopamine D2 / metabolism*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Sensory Receptor Cells / metabolism
  • Subtraction Technique


  • Radiopharmaceuticals
  • Receptors, Dopamine D2
  • Raclopride