Adverse effects of combined spinal-epidural versus traditional epidural analgesia during labor

Int J Gynaecol Obstet. 2009 Sep;106(3):242-5. doi: 10.1016/j.ijgo.2009.04.019. Epub 2009 May 28.


Objective: To compare two neuraxial block techniques during labor for maternal and fetal effects.

Methods: Women in labor at term with cephalic singleton fetuses were randomized (nonblinded) to receive either labor epidural (EPI) or combined spinal-epidural (CSE) analgesia. Primary outcome was prolonged deceleration (PD) of fetal heart rate. Outcomes also included hypotension, mode of delivery, and efficacy of analgesia by visual analog pain scale (VAPS) before and after block placement.

Results: Randomization occurred in 127 patients: 63 received EPI, 64 received CSE. There was no difference in the rate of PD in the EPI group compared with the CSE group (3.2% vs 6.2% respectively; P=0.43, RR 2.0; 95% CI 0.4-9.3), rate of cesarean delivery, or mean epidural duration. VAPS ratings were significantly lower in the CSE group.

Conclusions: There were no differences in the rate of PD or other adverse outcomes. Hypotension occurred more frequently with CSE during labor at term. The study supports both EPI and CSE during labor as safe and effective techniques for neuraxial analgesia.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Analgesia, Epidural / adverse effects*
  • Analgesia, Obstetrical / adverse effects*
  • Analgesia, Obstetrical / methods
  • Anesthesia, Spinal / adverse effects*
  • Bradycardia / chemically induced
  • Combined Modality Therapy
  • Female
  • Heart Rate, Fetal / drug effects*
  • Humans
  • Hypotension / chemically induced*
  • Middle Aged
  • Nerve Block / adverse effects
  • Pregnancy
  • Risk
  • Young Adult