Targeting vectors for cancer gene therapy

Front Biosci (Elite Ed). 2009 Jun 1;1:332-40.

Abstract

Establishment of a system that allows selective gene transfer to a tumor is expected to enable targeted therapy. Using a combination of fiber-modified adenovirus and antibody to a cell surface antigen, we have explored methods to enhance the selectivity of gene transfer. In addition, we aimed to establish a systematic screening method to search for antibody and cell surface target candidates for providing highly selective gene transfer to a variety of malignant tumors.

Publication types

  • Review

MeSH terms

  • Adenoviridae / genetics
  • Amino Acid Sequence
  • Antigens, Surface / genetics
  • Gene Transfer Techniques*
  • Genetic Therapy / methods*
  • Genetic Vectors / genetics
  • Genetic Vectors / therapeutic use*
  • Humans
  • Molecular Sequence Data
  • Neoplasms / genetics*
  • Neoplasms / therapy*

Substances

  • Antigens, Surface