Proliferation of cardiomyocytes: a question unresolved

Front Biosci (Elite Ed). 2009 Jun 1;1:528-36. doi: 10.2741/e49.


In the past, human heart has been considered a post-mitotic organ formed by cells, like adult cardiomyocytes, terminally differentiated and incapable of proliferation. This paradigm has been shaken by recent works indicating that postnatal adult cardiomyocytes are able to re-enter in the cell cycle and proliferate. In this view, the understanding of main candidates regulating cardiomyocyte cell cycle is of vital importance for future clinical approach.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Cell Cycle / physiology*
  • Cell Proliferation*
  • Gene Expression Regulation, Developmental / physiology*
  • Heart / growth & development*
  • Humans
  • Mitogen-Activated Protein Kinases / metabolism
  • Myocytes, Cardiac / cytology*
  • Myocytes, Cardiac / physiology*
  • Signal Transduction / physiology*


  • Mitogen-Activated Protein Kinases