The high rate of adverse drug events in children receiving prolonged outpatient parenteral antibiotic therapy for osteomyelitis

Pediatr Infect Dis J. 2009 Jun;28(6):539-41. doi: 10.1097/INF.0b013e318193ef38.


Forty-five children treated with 82 courses of 15 different antibiotics over 344 weeks during outpatient parenteral antibiotic therapy were evaluated for adverse drug events (ADE). Fifty-one percent of the courses had an associated ADE and 32.5% of the antibiotic courses were discontinued because of ADE. Vancomycin had the highest ADE rate at 85.7% and ceftriaxone had the highest ADE-related discontinuation rate at 66.7%. Cefazolin had the lowest rate of ADE and ADE-related discontinuation rates at 0% for both.

MeSH terms

  • Adolescent
  • Ambulatory Care*
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / therapeutic use
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Infusions, Parenteral*
  • Male
  • Osteomyelitis / diagnosis
  • Osteomyelitis / drug therapy*
  • Osteomyelitis / microbiology
  • Young Adult


  • Anti-Bacterial Agents