Progression of macular ischemia following intravitreal bevacizumab

Ophthalmic Surg Lasers Imaging. May-Jun 2009;40(3):316-8. doi: 10.3928/15428877-20090430-17.

Abstract

A 37-year-old woman with bilateral obliterative retinal vasculitis and macular ischemia received intravitreal bevacizumab for rapidly progressive neovascularization of the optic disc and vitreous hemorrhage in the left eye. One week after treatment, she presented with central scotoma and fluorescein angiography revealed increased parafoveal capillary dropout and progressive macular ischemia in the treated eye.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Angiogenesis Inhibitors / administration & dosage
  • Angiogenesis Inhibitors / therapeutic use*
  • Antibodies, Monoclonal / administration & dosage
  • Antibodies, Monoclonal / therapeutic use*
  • Antibodies, Monoclonal, Humanized
  • Bevacizumab
  • Disease Progression
  • Female
  • Fluorescein Angiography
  • Humans
  • Injections
  • Ischemia / physiopathology*
  • Laser Coagulation
  • Macula Lutea / blood supply*
  • Macular Edema / physiopathology
  • Neovascularization, Pathologic / drug therapy*
  • Optic Disk / blood supply*
  • Retinal Vasculitis / physiopathology
  • Vascular Endothelial Growth Factor A / antagonists & inhibitors
  • Visual Acuity
  • Vitreous Body
  • Vitreous Hemorrhage / drug therapy

Substances

  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Vascular Endothelial Growth Factor A
  • Bevacizumab