Morphological and immunohistochemical characterization of paraneoplastic cerebellar degeneration associated with Yo antibodies

Acta Neurol Scand. 2009 Jul;120(1):64-7. doi: 10.1111/j.1600-0404.2008.01138.x.


Introduction: Immunohistochemical studies of paraneoplastic cerebellar degeneration (PCD) are rare, and the findings vary.

Materials and methods: We performed morphological and immunohistochemical characterization of the brain, medulla and tumour of two patients with PCD, Yo antibodies and ovarian adenocarcinoma.

Results: The cerebellum of both patients had extensive loss of Purkinje cells. Microglia activation and T cells were found in the cerebellum, but B cells or deposits of IgG or complement were not detected. Microglia activation was also present in the brain stem and medulla. T cells were found in the ovarian adenocarcinoma.

Conclusion: PCD is characterized by loss of Purkinje cells and microglia activation, and the presence of T cells indicates cellular immune reactions in PCD and in ovarian cancer.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / immunology
  • Adenocarcinoma / pathology*
  • Aged, 80 and over
  • Autoantibodies / immunology*
  • Female
  • Gliosis / immunology
  • Gliosis / pathology
  • Humans
  • Immunohistochemistry
  • Microglia / immunology
  • Microglia / pathology
  • Middle Aged
  • Nerve Tissue Proteins / immunology*
  • Ovarian Neoplasms / immunology
  • Ovarian Neoplasms / pathology*
  • Paraneoplastic Cerebellar Degeneration / immunology
  • Paraneoplastic Cerebellar Degeneration / pathology*
  • Purkinje Cells / immunology
  • Purkinje Cells / pathology*


  • Autoantibodies
  • CDR2 protein, human
  • Nerve Tissue Proteins