Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 69 (11), 4682-90

Multipotent CD15+ Cancer Stem Cells in patched-1-deficient Mouse Medulloblastoma

Affiliations

Multipotent CD15+ Cancer Stem Cells in patched-1-deficient Mouse Medulloblastoma

Ryan J Ward et al. Cancer Res.

Abstract

Subpopulations of tumorigenic cells have been identified in many human tumors, although these cells may not be very rare in some types of cancer. Here, we report that medulloblastomas arising from Patched-1-deficient mice contain a subpopulation of cells that show a neural precursor phenotype, clonogenic and multilineage differentiation capacity, activated Hedgehog signaling, wild-type Patched-1 expression, and the ability to initiate tumors following allogeneic orthotopic transplantation. The normal neural stem cell surface antigen CD15 enriches for the in vitro proliferative and in vivo tumorigenic potential from uncultured medulloblastomas, supporting the existence of a cancer stem cell hierarchy in this clinically relevant mouse model of cancer.

Similar articles

See all similar articles

Cited by 75 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback