[Mode of action of hypoglycemic sulfanilamides]

Therapie. 1991 Jul-Aug;46(4):311-4.
[Article in French]

Abstract

Sulfonylureas act as hypoglycemic agents by stimulating insulin secretion and improving insulin sensibility by a post-receptor mechanism. Their long term results mainly depend on extra-pancreatic mechanisms. Moreover they indirectly decrease triglyceridemia. Glipizide and gliclazide enhance fibrinolysis. Gliclazide also inhibits platelet aggregation and adhesion. The best indication of sulfonylureas is non insulin dependent diabetes with normal weight.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Fibrinolysis / drug effects
  • Glucose / metabolism
  • Hemostasis / drug effects
  • Humans
  • Hypoglycemia / drug therapy
  • Hypoglycemia / etiology
  • Insulin / metabolism
  • Sulfonylurea Compounds / pharmacology
  • Sulfonylurea Compounds / therapeutic use*

Substances

  • Insulin
  • Sulfonylurea Compounds
  • Glucose