Degradation of activated protein kinases by ubiquitination

Annu Rev Biochem. 2009;78:435-75. doi: 10.1146/annurev.biochem.013008.092711.


Protein kinases are important regulators of intracellular signal transduction pathways and play critical roles in diverse cellular functions. Once a protein kinase is activated, its activity is subsequently downregulated through a variety of mechanisms. Accumulating evidence indicates that the activation of protein kinases commonly initiates their downregulation via the ubiquitin/proteasome pathway. Failure to regulate protein kinase activity or expression levels can cause human diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Down-Regulation*
  • Humans
  • Protein Kinases / metabolism*
  • Signal Transduction*
  • Ubiquitination*


  • Protein Kinases