At loose ends: resecting a double-strand break

Cell. 2009 May 29;137(5):807-10. doi: 10.1016/j.cell.2009.05.007.


Double-strand break (DSB) repair is critical for maintaining genomic integrity and requires the processing of the 5' DSB ends. Recent studies have shed light on the mechanism and regulation of DNA end processing during DSB repair by homologous recombination.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Archaea / metabolism
  • Cell Cycle
  • DNA Breaks, Double-Stranded*
  • DNA Repair*
  • Humans