Insulin-like growth factor-I, insulin-like growth factor binding protein-3 and growth in obese children before and after reduction of overweight

J Pediatr Endocrinol Metab. 2009 Mar;22(3):225-33. doi: 10.1515/jpem.2009.22.3.225.


Little longitudinal information is available on changes of growth, insulin-like growth factor-I (IGF-I), its main binding protein (IGFBP-3) and their relationships to leptin and insulin in obese children reducing their overweight. We compared these parameters between baseline and after participating in a one-year lifestyle intervention in 319 obese children. The control group comprised 52 lean children. Obese children demonstrated significantly increased IGFBP-3, leptin, and insulin concentrations and were taller compared to the lean children, while they did not differ in respect to their IGF-I concentrations. Reduction of overweight was associated with a significant decrease of IGFBP-3 SDS, leptin, and insulin concentrations. IGF-I SDS and height SDS did not change after weight loss.

Conclusions: IGFBP-3, leptin and insulin concentrations are increased in obese children and normalized in weight loss demonstrating the reversibility of these alterations. Weight loss due to lifestyle intervention was not associated with growth disturbances.

Trial registration: NCT00435734.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Body Constitution / physiology*
  • Body Height / physiology
  • Body Weight / physiology
  • Child
  • Female
  • Humans
  • Insulin / blood
  • Insulin-Like Growth Factor Binding Protein 3 / blood*
  • Insulin-Like Growth Factor I / metabolism*
  • Leptin / blood
  • Life Style*
  • Male
  • Obesity / blood*
  • Obesity / diagnosis
  • Obesity / therapy
  • Weight Loss / physiology*


  • Insulin
  • Insulin-Like Growth Factor Binding Protein 3
  • Leptin
  • Insulin-Like Growth Factor I

Associated data